Cannabis in Maryland is legal for medical use and recreational use. Possession of up to 1.5 ounces and cultivation of up to 2 plants is legal for adults 21 years of age and older.

In 2013, a state law was enacted to establish a state-regulated medical cannabis program. The program, known as the Natalie M. LaPrade Maryland Medical Cannabis Commission (MMCC), became operational on December 1, 2017.

A majority of voters approved the 2022 Maryland Question 4 referendum to legalize recreational use of cannabis on November 8, 2022, with 67.2% of voters in favor and 32.8% against. It took effect on July 1, 2023. Under Question 4, adults 21 years of age and older are permitted to grow up to two cannabis plants out of public view, and possess no more than 1.5 ounces of recreational cannabis on their person. Possession of between 1.5-2.5 ounces is punishable by a civil fine of up to $250, and over 2.5 ounces is punishable by up to a $1000 fine and up to 6 months in jail. Additionally, a companion bill triggered upon passage of the referendum included a provision to automatically expunge all cases in which possession of cannabis was the only charge, as well as allow for individuals incarcerated for cannabis possession to petition for resentencing.