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Best known for its spicy and peppery note, caryophyllene is also found in black pepper, cinnamon, cloves, and spices like oregano, basil, and rosemary. Beta-caryophyllene binds to Cannabinoid Type-2 (CB2) receptors, which makes it an ingredient in anti-inflammatory topicals and creams. Caryophyllene is the only terpene that binds to cannabinoid receptors. Besides its analgesic and anti-anxiety properties, some studies have found that caryophyllene has some very promising properties when it comes to alcoholism rehabilitation. A group of scientists performed research on mice and found that this terpene reduces voluntary intake of alcohol. They even recommended caryophyllene for treating alcohol withdrawal symptoms.

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