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"Humulene"

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Industry Terms

Humulene was the first terpene found in hops. Its aroma contains earthy, woody, and spicy notes. Besides cannabis, it can be also found in clove, sage, and black pepper. It has a variety of medical properties. Early research has shown humulene to be anti-proliferative, meaning it prevents cancer cells from growing. Also, it proved to be effective in suppressing appetite, making it a potential weight loss tool. Furthermore, like many other cannabis terpenes mentioned above, it also reduces inflammation, relieves pain, and fights bacterial infections.

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Humulene (Wikipedia)
Not to be confused with humulone.

Humulene, also known as α-humulene or α-caryophyllene, is a naturally occurring monocyclic sesquiterpene (C15H24), containing an 11-membered ring and consisting of 3 isoprene units containing three nonconjugated C=C double bonds, two of them being triply substituted and one being doubly substituted. It was first found in the essential oils of Humulus lupulus (hops), from which it derives its name. Humulene is an isomer of β-caryophyllene, and the two are often found together as a mixture in many aromatic plants.

Humulene
Humulene
Humulene
Names
IUPAC name
[1(11)E,4E,8E]-Humula-1(11),4,8-triene
Systematic IUPAC name
(1E,4E,8E)-2,6,6,9-Tetramethylcycloundeca-1,4-8-triene
Other names
alpha-Caryophyllene; 3,7,10-Humulatriene
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.027.106 Edit this at Wikidata
UNII
  • InChI=1S/C15H24/c1-13-7-5-8-14(2)10-12-15(3,4)11-6-9-13/h6-7,10-11H,5,8-9,12H2,1-4H3/b11-6+,13-7+,14-10+ checkY
    Key: FAMPSKZZVDUYOS-HRGUGZIWSA-N checkY
  • InChI=1/C15H24/c1-13-7-5-8-14(2)10-12-15(3,4)11-6-9-13/h6-7,10-11H,5,8-9,12H2,1-4H3/b11-6+,13-7+,14-10+
    Key: FAMPSKZZVDUYOS-HRGUGZIWBF
  • C\1=C/C(C)(C)C/C=C(/CC/C=C(/C/1)C)C
Properties
C15H24
Molar mass 204.357 g·mol−1
Appearance Pale yellowish green clear liquid
Density 0.886 g/cm3
Melting point < 25 °C (77 °F; 298 K)
Boiling point 106 to 107 °C (223 to 225 °F; 379 to 380 K) at 5 mmHg
Hazards
Lethal dose or concentration (LD, LC):
>48 mg/kg
Safety data sheet (SDS) MSDS
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)
Humulene (Wiktionary)

English

Noun

humulene (countable and uncountable, plural humulenes)

  1. A naturally-occurring monocyclic sesquiterpene found in the essential oils of Humulus lupulus (hops).

Related terms

  • humulone
 Read More
Caryophyllene, α-Humulene, α-Caryophyllene, Humulon, α-Humulon

Humulene

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What is this "Wiki" & how does the cannabis community benefit?

The Green CulturED Wiki enables you to explore, learn, and share through a knowledge base tailored to the cannabis industry. It functions like an encyclopedia, lexicon, glossary, wiki, or dictionary. This tool is useful for industry learners and professionals to learn more about resources, programs, and terms specifically in the cannabis sector.

Yes, new terms can be added by crafting individual entries, each with its own dedicated page and unique URL. By sharing resources, information, and industry information, users are able to foster community, growth, and learning. Once submitted, a glossary term is reviewed by the Green CulturED team, which will then approve or deny the submission. 

While the Green CulturED Community Wiki does not impose specific content restrictions, it is essential to adhere to general web content guidelines, which include avoiding misinformation and respecting copyright laws. For cannabis-related glossaries, it’s critical to ensure the accuracy and legality of the information presented. In addition, common courtesy and “netiquette” are part of our community user agreement, and it is crucial to maintain those levels of respect when adding new terms, comments, etc.

Glossary term categories serve as a reference tool that enhances usability, navigability, and educational value by organizing terms into groups such as industry brands, consulting firms, and seed banks.

The Green CulturED Wiki supports comments on individual glossary terms, enabling users to engage in discussions or leave feedback. This feature fosters collaborative learning and knowledge sharing within the cannabis community.
If you encounter incorrect or outdated information, please contact the site administrators directly or use the commenting feature to report inaccuracies for review and correction. Green CulturED Wiki allows for revisions, enabling updates and corrections.
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