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Bioburden means the total number of microorganisms associated with a specific item prior to sterilization. The numerous ways a cannabis product can acquire a microbial bioburden such as raw materials, processing, and packaging, can make contamination control every day and all year round. Sensitive locations such as cleanrooms need to conform to a range of local and international standards such as ISO standards or FDA guidance to ensure that they can operate consistently in an environment free from airborne hazards such as bacteria, yeast, and mold.

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