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Paraquat, a term that might not roll off the tongue easily, is a powerful herbicide that has been a staple in agricultural weed control since its introduction in the 1960s. The name “Paraquat” is derived from its chemical structure, specifically the para-position of the quaternary ammonium groups. While it has been praised for its effectiveness in eliminating unwanted plants, its use in the cannabis industry has been met with significant scrutiny. This is due to its high toxicity and the potential health risks it poses to both consumers and the environment. Over the years, the meaning of Paraquat has evolved, especially within the cannabis community, where there’s a growing emphasis on organic and sustainable farming practices. As a result, many cannabis cultivators are moving away from using Paraquat, opting instead for safer, more #2excludeGlossary alternatives. This shift highlights the industry’s commitment to providing consumers with cleaner, healthier products. [Source: Environmental Protection Agency]
Paraquat (trivial name; /ˈpærəkwɒt/), or N,N′-dimethyl-4,4′-bipyridinium dichloride (systematic name), also known as methyl viologen, is a toxic organic compound with the chemical formula [(C6H7N)2]Cl2. It is classified as a viologen, a family of redox-active heterocycles of similar structure. It is one of the most widely used herbicides worldwide. It is quick-acting and non-selective, killing green plant tissue on contact.
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Names | |
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Preferred IUPAC name
1,1′-Dimethyl[4,4′-bipyridine]-1,1′-diium dichloride | |
Other names
Paraquat dichloride; Methyl viologen dichloride; MVCl2; Crisquat; Dexuron; Esgram; Gramuron; Ortho Paraquat CL; Para-col; Pillarxone; Tota-col; Toxer Total; PP148; Cyclone; Gramixel; Gramoxone; Pathclear; AH 501; Bai Cao Ku.
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Identifiers | |
3D model (JSmol)
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ChEBI | |
ChEMBL | |
ChemSpider |
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ECHA InfoCard | 100.016.015 ![]() |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C12H14Cl2N2 | |
Molar mass | 257.16 g·mol−1 |
Appearance | Yellow solid |
Odor | faint, ammonia-like |
Density | 1.25 g/cm3 |
Melting point | 175 to 180 °C (347 to 356 °F; 448 to 453 K) |
Boiling point | > 300 °C (572 °F; 573 K) |
High | |
Vapor pressure | <0.0000001 mmHg (20 °C) |
Hazards | |
Occupational safety and health (OHS/OSH): | |
Main hazards
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Toxic, environmental hazard |
GHS labelling: | |
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H301, H311, H315, H319, H330, H335, H372, H410 | |
P260, P273, P280, P284, P301+P310, P305+P351+P338 | |
Lethal dose or concentration (LD, LC): | |
LD50 (median dose)
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57 mg/kg (rat, oral) 120 mg/kg (mouse, oral) 25 mg/kg (dog, oral) 22 mg/kg (guinea pig, oral) |
LC50 (median concentration)
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3 mg/m3 (mouse, 30 min respirable dust) 3 mg/m3 (guinea pig, 30 min respirable dust) |
LCLo (lowest published)
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1 mg/m3 (rat, respirable dust, 6 h) 6400 mg/m3 (rat, nonrespirable dust, 4 h) |
NIOSH (US health exposure limits): | |
PEL (Permissible)
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TWA 0.5 mg/m3 (resp) [skin] |
REL (Recommended)
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TWA 0.1 mg/m3 (resp) [skin] |
IDLH (Immediate danger)
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1 mg/m3 |
Safety data sheet (SDS) | Aldrich MSDS |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Paraquat is highly toxic to humans and other animals. The toxicity and lethality depends on the dose and how the herbicide is absorbed by the body. In humans, paraquat damages the mouth, stomach, and intestines if it is ingested orally. Once absorbed in the body, paraquat causes particular damage to the lungs, kidneys, and liver. Paraquat's lethality is attributed to its enhancing production of superoxide anions and human lung cells can accumulate paraquat. Paraquat exposure has been strongly linked to the development of Parkinson's disease.
Paraquat may be in the form of salt with chloride or other anions; quantities of the substance are sometimes expressed by cation mass alone (paraquat cation, paraquat ion). The name is derived from the para positions of the quaternary nitrogens.
English
Etymology
From a trademark.
Noun
paraquat (countable and uncountable, plural paraquats)
- (chemistry) A poisonous yellow herbicide derived from bipyridine